Table 1:
Lenalidomide Dose Escalation Schema
| Dose Level | Dose of Radiation (Gy) | Dose of lenalidomide during radiation (continuous daily dosing) | Dose of maintenance lenalidomide (28-day course; 21 days on and 7 days off) |
|---|---|---|---|
| −1 | 54–59.4 | 10 mg/m2/ daily | 116 mg/m2 |
| 0 | 54–59.4 | 15 mg/m2/ daily | 116 mg/m2 |
| 1* | 54–59.4 | 32 mg/m2/ daily | 116 mg/m2 |
| 2 | 54–59.4 | 52 mg/m2/ daily | 116 mg/m2 |
| 3 | 54–59.4 | 88 mg/m2/ daily | 116 mg/m2 |
| 4 | 54–59.4 | 116 mg/m2/ daily | 116 mg/m2 |
Starting Dose Level