Table 4:
Toxicities at Least Possibly Attributed to Lenalidomide (at any time while on study)
| Toxicity | Total No. of Patients | Grade (by incident) | |||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| Abdominal pain | 2 | 2 | |||
| Alanine aminotransferase increased | 8 | 9 | |||
| Anorexia | 4 | 5 | |||
| Back pain | 1 | 1 | |||
| Blood bilirubin increased | 2 | 2 | 2 | ||
| Blurred vision | 1 | 1 | |||
| Bone pain | 1 | 1 | |||
| Cardiac disorders | 1 | 1 | |||
| Constipation | 16 | 17 | 3 | ||
| Delirium | 1 | 1 | |||
| Depression | 1 | ||||
| Diarrhea | 4 | 4 | |||
| Dry skin | 1 | 1 | |||
| Dysgeusia | 2 | 1 | 1 | ||
| Fatigue | 17 | 21 | 4 | ||
| Gastrointestinal pain | 1 | 1 | |||
| Headache | 7 | 9 | |||
| Hemolysis | 1 | 1 | |||
| Hyperhidrosis | 1 | 1 | |||
| Hypersomnia | 1 | 1 | |||
| Hypertension | 1 | 1 | |||
| Infections and infestations - Gastroenteritis | 1 | 1 | |||
| Infections and infestations - Staphylococcus aureus | 1 | 1 | |||
| Insomnia | 1 | 1 | |||
| Lymphocyte count decreased | 15 | 22 | 22 | 12 | 2 |
| Nausea | 4 | 4 | |||
| Neutrophil count decreased | 8 | 2 | 5 | 6 | 1 |
| Oral pain | 1 | 1 | |||
| Pain - L Lower jaw pain | 1 | 1 | |||
| Palmar-plantar erythrodysesthesia | 1 | 1 | |||
| Platelet count decreased | 17 | 29 | 7 | 9 | 2 |
| Pruritus | 2 | 2 | |||
| Rash maculo-papular | 3 | 3 | |||
| Skin and subcutaneous tissue disorders | 3 | 4 | 3 | ||
| Skin hyperpigmentation | 1 | 1 | |||
| Stomach pain | 2 | 3 | |||
| Voice alteration | 1 | 1 | |||
| Vomiting | 2 | 2 | 1 | ||
| White blood cell decreased | 14 | 26 | 14 | 1 | |