Fig. 3. (A) Schematic illustration of the intracellular survivin mRNA triggered PER based-DNA machine system for sensitive imaging of survivin mRNA. (B) Confocal laser scanning microscopy (CLSM) images of HeLa cells. The HeLa cells were pretreated with 10 mM Mg2+ and 5 μM calcimycin for 30 min and then incubated for 3 h with different nanoparticles: (a) BSA + KFP@ZIF-8/primer + MB NPs; (b) BSA + KFP@ZIF-8/HP + MB NPs; (c) BSA@ZIF-8/HP + primer + MB NPs; and (d) BSA + KFP@ZIF-8/HP + primer + MB NPs. Scale bar: 20 μm.
