Figure 5.

Schematic summary of how fisetin exerts an anti-AS effect in apoE^-/- mice fed with a high-fat diet. Fisetin treatment ameliorated lipid accumulation in the atherosclerotic plaque by downregulating PCSK9 and LOX-1, which reduces the uptake of ox-LDL by macrophages, thereby reducing foam cell formation. Fisetin also improves senescence by downregulating the aging-related proteins p53, p21, and p16 in aortic tissue. AS, Atherosclerosis; PCSK9, proprotein convertase subtilisin/kexin type 9; LOX-1, lectin-like oxidized low-density lipoprotein receptor-1; ox-LDL, oxidized low-density lipoprotein; p53, tumor suppressor protein p53; p21, cyclin-dependent kinase inhibitor 1A; p16, multiple tumor suppressor-1.