Figure A1.

Hypoxia signatures associate with poor outcome and stroma activation in PDAC. (A) PDAC samples from the Bailey dataset were used. Kaplan–Meier survival analysis was performed by a hypoxia geneset expression and dichotomized by median. The curves are shown using genesets response to hypoxia, reactome regulation of hypoxia inducible factor hif by oxygen (B), reactome regulation of gene expression by hypoxia inducible factor (C), and semenza hif1 targets (D). (E) The correlation between normal/activated stroma genesets and hypoxia KEGG signaling pathway geneset was analyzed in six datasets as indicated. p value is indicated by color, correlation coefficient (R) by size of dot.