Table 2. Results of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses of the most significant module.
| Pathway ID | Pathway description | Count in gene set | p-value | FDR | DEGs |
|---|---|---|---|---|---|
| GO:0007155 | Cell adhesion | 5 | 1.37E−06 | 0.001121514 | COL6A3, COL12A1, VCAN, POSTN, THBS2 |
| GO:0001501 | Skeletal system development | 3 | 3.80E−04 | 0.310820683 | FBN1, VCAN, COL5A2 |
| GO:0030199 | Collagen fibril organization | 2 | 0.017003019 | 13.1195401 | COL5A2, CDH11 |
| GO:0005201 | Extracellular matrix structural constituent | 4 | 2.39E−06 | 0.001487027 | COL3A1, FBN1, VCAN, COL5A2 |
| GO:0005509 | Calcium ion binding | 4 | 0.003312243 | 2.045566581 | FBN1, VCAN, THBS2, CDH11 |
| GO:0005578 | Proteinaceous extracellular matrix | 6 | 1.81E−08 | 1.29E−05 | COL3A1, COL6A3, FBN1, COL12A1, VCAN, POSTN |
| GO:0005581 | Collagen trimer | 3 | 3.07E−04 | 0.217600344 | COL3A1, COL6A3, COL12A1 |
| GO:0031012 | Extracellular matrix | 3 | 0.001912518 | 1.350246354 | FBN1, COL12A1, THBS2 |
| GO:0005615 | Extracellular space | 4 | 0.008881226 | 6.138544445 | COL6A3, FBN1, COL12A1, POSTN |
| GO:0005604 | Basement membrane | 2 | 0.032936583 | 21.16653102 | FBN1, THBS2 |
| gga04512 | ECM–receptor interaction | 4 | 4.51E−05 | 0.019602271 | COL3A1, COL6A3, THBS2, COL5A2 |
| gga04510 | Focal adhesion | 4 | 7.12E−04 | 0.309146908 | COL3A1, COL6A3, THBS2, COL5A2 |
Notes.
Abbreviation
- FDR
- false discovery rate