Table 5.
Binary logistic regression analysis for factors associated with risk of impairment in various IQ domains at 5 years of longitudinal follow-up
| Parameter | Mean Improvement in IQ Scores at 5 Years from Baseline | ||||||
|---|---|---|---|---|---|---|---|
| FSIQ/GQ | P-value | VQ/MQ | P-value | PQ | P-value | ||
| Age | <13 y | 3.5 | 0.03* | −5.0 | 0.02* | 24.0 | 0.11 |
| >13 y | 16.1 | 36.0 | 15.8 | ||||
| Sex | Male | 10.1 | 0.80 | −1.6 | 0.97 | 18.3 | 0.87 |
| Female | 8.5 | −2.0 | 19.7 | ||||
| Histology | Glioma | 9.2 | 0.06 | −2.8 | 0.25 | 17.7 | 0.11 |
| Craniopharyngioma | 8.1 | 0.75 | 20.6 | ||||
| Site | Cerebral/cerebellar | 11.8 | 0.63 | 0.0 | 0.71 | 14.2 | 0.30 |
| Sellar/suprasellar | 8.9 | 4.0 | 21.6 | ||||
| Hydrocephalus | Mild/moderate | 11.7 | 0.24 | 3.6 | 0.26 | 22.7 | 0.29 |
| Severe | 7.8 | −12.2 | 12.6 | ||||
| Mean left hippocampus dose | <30 Gy | 14.8 | 0.04* | 3 | 1.00 | 25.0 | 0.03* |
| >30 Gy | 1.25 | −6.3 | 7.8 | ||||
| Mean right hippocampus dose | <33 Gy | 11.4 | 0.4 | 7.8 | 0.986 | 19.6 | 0.29 |
| >33 Gy | 8.4 | −20.7 | 17.2 |
Note: Minus sign ndicates decline in IQ at 5 years from baseline.