Table 2.
Characteristics of the included studies organized alphabetically.
| Author, Year | Country | Study Design |
Type of Intervention | Sample Size | Age in Years | Clinical Info Included Patients |
Cancer Treatment |
|---|---|---|---|---|---|---|---|
| Capozzi, 2016 [10] | Canada | Pilot RCT | Exercise and nutrition | 60 male 82% |
Mean (SD) 56.1 (9.2) |
Diagnosis (n): Larynx-hypopharynx (6), Nasopharynx (4), Oral (8), Oropharynx (29), Other (6), Unknown origin (7) Stage (n): I-III (11), IV (48) Histology: NA |
RT (n = 16) CRT (n = 44) |
| Cereda, 2018 [23] | Italy | RCT | Nutrition | 159 male 72% |
Mean (SD) Counselling 63.8 (12.7); counselling + ONS 66.5 (14.5) |
Diagnosis (n): Hypopharynx (13), Larynx (41), Naso- oropharynx (44), Oral (29), Other (32) Stage (n): 0-II (76), III (40), IV (34) Histology (n): Squamous (124), Lymphoma (20), other (15) |
RT (n = 98) and CRT (n = 61) |
| Daly, 1984 [21] | USA | RCT | Nutrition | 40 male 80% |
Mean (SD), Intervention 53 (15) Control 55 (13) |
Diagnosis (n): Nasopharynx (15), Other (25) Stage (n): II (2), III (9), IV (28) Histology: NA |
All RT |
| Hearne, 1989 [24] | USA | RCT | Nutrition | 31 male 77% |
Mean (range), Intervention 52.1 (22–74) Control 56.1 (37–83) |
Diagnosis (n): Nasopharynx (9), Other (22) Stage (n): III (11), IV (20) Histology: NA |
All RT |
| Isenring, 2003 [25] |
Australia | RCT | Nutrition | 36 male 81% |
Mean (SD), 63 (15) |
Diagnosis: NA Stage: NA Histology: NA |
All RT |
| Jiang, 2018 [26] | China | RCT | Nutrition | 100 male 69% |
Mean (SD), Intervention 46.7 (10.9)) Control 48.2 (11.1) |
Diagnosis: Nasopharynx Stage: III (43), IVa-b (57) Histology: NA |
All CRT |
| Ravasco, 2005 [27] | Portugal | RCT | Nutrition | 75 male 80% |
Mean (SD) 60 (11) |
Diagnosis (n NA): Larynx, Oropharynx, Nasopharynx, Tongue Stage (n): I-II (30), III-IV (45) Histology: NA |
All RT (all pre-vious CT) |
| Rogers, 2013 [28] | USA | Pilot RCT | Exercise and nutrition | 15 male 80% |
Mean (SD) 60.5 (12.5) |
Diagnosis (n): Nasopharynx, scalp and salivary glands (5), Other (10)Stage (n): I-II (7), III -IV (8) Histology: NA |
RT (n = 11), CRT (n = 4) |
| Roussel, 2017 [29] | France | RCT | Nutrition | 87 male 81% |
Mean (SD) 60 (10) | Diagnosis (n): Hypopharynx (11), Larynx (19), Oral (9), Oropharynx (40), Nasopharynx (2), Sinus (2), Unknown origin (4) Stage (n): I-II (14), III (14), IV-V (59) Histology: NA |
RT (n = 28), CRT (n = 59) |
| Sandmaell, 2017 [9] | Norway | Pilot RCT | Exercise and nutrition | 41 male 61% |
Mean (SD) 63.2 (9.3) | Diagnosis (n): Larynx (4), Nasal (1), Oral (5), Pharynx (20), Pharynx and larynx (1), Salivary glands (8), Unknown origin (2) Stage and histology: NA |
RT (n = 24), CRT (n = 17) |
| Samuel, 2019 [22] | India | RCT | Exercise | 148 | Mean (SD) Intervention: 52.8 (9.7) Control: 52.8 (10.5) |
Diagnosis (n): Larynx (28), Oropharynx (120) Stage (n): III (38), IVa (94), IVb (16) Histology: NA |
All CRT |
| Samuel, 2013 [30] | India | RCT | Exercise | 48 male 88% |
Mean (SD) Intervention: 51.7 (10) Control: 52.5 (8.27) |
Diagnosis: NA Stage: NA Histology: NA |
All CRT |
| Zhao, 2016 [31] | USA | Pilot RCT | Exercise and nutrition | 18 male 94% |
Mean (SD) 57 (11) | Diagnosis (n): Larynx (1), Pharynx (15), Unknown origin (1) Stage (n): III (4), IV (7) Histology (n): NA |
All CRT |
Abbreviations: NA: not available; RT: radiotherapy; CRT: chemo/radiotherapy; RCT: randomized clinical trial.