Table 4.

Clinical improvement with folinic acid treatment (based on usual clinical exam).

	Before Treatment	After Treatment (2 Months)
Seizure	++++	+
Myoclonia	+++	▪ less important ▪ less frequent ▪ less invasive ⇨ up to the lack of myoclonia
Tremor	+++	+
Cognitive functions	Non measurable (due to seizure, myoclonia, fatigue, tremor, language skills, neuromotor skills and limited interaction)	▪ improvement
Language skills	▪ difficulties to speak ▪ no spontaneous question ▪ screaming, laughing and moaning.	▪ speaks more fluently ▪ makes spontaneous questions ▪ makes short sentences.
Motor coordination	▪ motor coordination disorder	▪ better motor coordination: hands reuse (for instance: she holds objects more easily, as a book, turns pages, eats alone, holds a pencil, stacks cubes, switches objects from one hand to another hand and draws on a board)
Neuromotor skills	▪ no autonomous walking ▪ needs a wheelchair ▪ falls down (more than 2 per day)	▪ improvement ▪ walks alone or with partial assistance ▪ stands upright
Interaction	▪ no interaction ▪ no eye contact	▪ interactions around her

+: frequency.