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EMPA does not improve nephropathy in T1D and T2D mouse models. (A–D) Albumin-to-creatinine ratio (ACR) (A), representative examples of glomerular periodic acid-Schiff (PAS) staining (B), glomerular area (C), and mesangial index (D) in T1D (db/+ STZ), T2D (db/db), and control (db/+) mice with/without EMPA; n = 4–10 mice per group; * p < 0.05, *** p < 0.001, **** p < 0.0001 for untreated control vs. untreated T1D and T2D; by one-way ANOVA. Data are expressed as the mean ± s.e.m.
