ADT	Androgen-deprivation therapy
4EBP1	4E (eIF4E)-binding protein 1
AMO	Antisense anti-miR oligonucleotide
AR	Androgen receptor
BER	Base excision repair
BRCA1	Breast cancer susceptibility protein 1
BRCA2	Breast cancer susceptibility protein 2
C2D	C2 domain
Cas9	CRISPR-associated protein 9,
CHK1	Cyclin D1 and checkpoint kinase 1
cIAP-1	Cellular inhibitor of apoptosis protein-1
CRISPR	Clustered regularly interspaced short palindromic repeat
CRPC	Castrate-resistant prostate cancer
CTC	Circulating tumor cell
CXCL8	C-X-C motif chemokine ligand 8, interleukin 8
DDR	DNA damage response
DEPTOR	Disheveled, EGL-10 and pleckstrin (DEP) domain-containing mTOR-interacting protein
DHT	Dihydrotestosterone
DRE	Digital rectal examination
DSBs	Double-strand breaks
EGFR	Epidermal growth factor receptor
EMT	Epithelial-to-mesenchymal transition
ECM	Extracellular matrix
FISH	Fluorescence in situ hybridization
FOXO	Forkhead box protein O
GAS6	Growth arrest-specific protein 6
GSK3β	Glycogen synthase kinase 3 beta
GPCR	G-protein coupled receptor
HER2	Human epidermal growth factor receptor 2
HRR	Homologous recombination repair
IHC	Immunohistochemistry
IL6	Interleukin 6
IL8	Interleukin 8
ITSN	Intersectin
LNA	Locked nucleic acid
MAN2C1	α-mannosidase 2C1
MAPK	Mitogen-activated protein kinase
MAPKAP1	Mammalian stress-activated protein kinase-interacting protein 1
mCRPC	Metastatic castrate-resistant prostate cancer
MDSC	Myeloid-derived suppressor cells
MEF	Mouse embryonic fibroblast
miRNA	Micro ribonucleic acid
mHSPC	Metastatic hormone-sensitive prostate cancer
mLST8	Mammalian lethal with SEC13 protein 8
MMR	Mismatch repair
mpMRI	Multiparametric MRI
mTOR	Mammalian target of rapamycin
mTORC1	Mammalian target of rapamycin complex 1
mTORC2	Mammalian target of rapamycin complex 2
NER	Nucleotide excision repair
NF-κB	Nuclear factor kappa light chain enhancer of activated B cells
NHEJ	Non-homologous end joining
NSCLC	Non-small-cell lung carcinoma
OncomiRs	Oncogenic miRNAs
P	Phosphorylation event
PBD	PIP2-binding domain
PARP	Poly-ADP ribose polymerase
PDK1	Phosphoinositide-dependent kinase 1
PH domain	Pleckstrin homology domain
Phos D	Phosphatase domain
PI3K	Phosphoinositide 3-kinase
PIP2	Phosphatidylinositol 4,5-bisphosphate
PIP3	Phosphatidylinositol 3,4,5-trisphosphate
PKB	Protein kinase B, AKT
PKC	Protein kinase C
PKCε	Protein kinase C epsilon
PKCζ	Protein kinase C zeta
PRAS40	Proline-rich AKT substrate of 40 kDa
PREX1	PIP3-dependent Rac exchanger 1
PREX2	PIP3-dependent Rac exchanger 2
PSA	Prostate-specific antigen
PTEN	Phosphatase and tensin homologue deleted on chromosome 10
RAPTOR	Regulatory-associated protein of mTOR
RBD	Ras-binding domain
RHEB	Ras homolog enriched in brain
RICTOR	Rapamycin-insensitive companion of mTOR
rPFS	Radiographic progression-free survival
RFS	Recurrence-free survival
RTK	Tyrosine kinase receptor
S6K	Ribosomal protein S6 kinase/p70 ribosomal S6 kinase
SGK1	Serum- and glucocorticoid-regulated kinase 1
SGK2	Serum- and glucocorticoid-regulated kinase 2
SGK3	Serum- and glucocorticoid-regulated kinase 3
siRNA	Small interfering RNA
SMIR	Small-molecule inhibitors of miRNA
SRC-3	Steroid receptor co-activator 3
SSBs	Single-strand breaks
TAM	Tumor-associated macrophage
TSC1	Tuberous sclerosis complex 1
TSC2	Tuberous sclerosis complex 2
TSIs	Tumor–stroma interactions
VAV3	Vav guanine nucleotide exchange factor 3