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. 2020 Oct 22;12(11):3082. doi: 10.3390/cancers12113082

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Potential mechanisms for obesity associations with ALL. The adipocytes secrete chemokines that can attract leukemia cells, including cysteine-X-cysteine (C-X-C) motif chemokine 12 (CXCL12). Adipose tissue-infiltrating Natural Killer (NK) cells secrete macrophage inflammatory protein-1 alpha (MIP-1α), another chemokine for leukemia cells. Obesity is also associated with reduced numbers and cytotoxic activity of NK cells. Adipose-derived stromal/stem cells (ASC) secrete factors that promote the proliferation of lymphoblasts.