Table 2.

Birth Weight and the Risk of Development of ALL.

Author (Reference)	Study Design	Populations	Findings
Hjalgrim et al. [43]	Meta-analysis	18 studies n = 10,282 Age: 0–29 years	BWt > 4000 was associated with a trend of higher risk of ALL (OR 1.26, 95% CI 1.17–1.37)
Caughey et al. [44]	Meta-analysis	32 studies n = 16,501 Leukemias (n = 10,974 ALL) Age: ≤ 30 years	Significant odds for the association of high BWt with ALL risk (OR 1.23, 95% CI 1.15–1.32)
Milne et al. [45]	CCS	n = 519 patients Age: 0–14 years	OR for 1 SD increase in proportion to optimal BWt 1.18 (95% CI 1.04–1.35, p < 0.05). However, faster fetal growth, instead of BWt, was the factor associated with ALL risk
Jiménez-Hernández et al. [46]	CCS	n = 2910 children Age: 0–18 years	ALL is associated with a birth weight ≥ 2500 g (OR 2.06, 95% CI 1.59–2.66) Birth weight ≥ 3500 g was also associated with ALL OR 1.19 (95% CI: 1.00–1.41)
Sprehe et al. [47]	RCR	n = 13,988 children Age < 5 years at cancer diagnosis + age-matched controls	Increased risk of ALL was associated with LGA compared to AGA LGA (<4000g) OR 1.5 (95% CI: 0.97–2.52, p = 0.0005) LGA (>4000g) OR 1.67 (95% CI: 1.29–2.16, p = 0.0005)

Abbreviations: BWt, birth weight; OR, odds ratio; CI, confidence interval; SD, standard deviation; CCS, case-control study; LGA, large for gestational age; AGA, appropriate for gestational age; RCR, retrospective chart review.