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. 2020 Oct 22;56(11):555. doi: 10.3390/medicina56110555

Figure 1.

Figure 1

Sign determination for FIE (D) with magnitude formulation. The rules for determining the sign of FIE on day, D, throughout a cycle are shown. Up arrow is +, down arrow is −. The arrows indicate the possible sign combinations for the differences in the serum E2 levels for intervals, D-2 to D-1, and D-1 to D. The resulting signs for FIE can be +, −, or ind (indeterminate). The delta values for D-1 and D are the normalized differences: Delta (D-1) = (E2 on D-1 − E2 on D-2)/E2 on D-2 and Delta(D) = (E2 on D − E2 on D-1)/E2 on D-1. The magnitude of FIE is the magnitude of the product: Delta(D) x Delta(D-1) × 100.