Table 1.
Day of Cycle | a Mean E2 Dighe (pg/mL) | Mean E2 Dighe (pmol/L) | b Delta (D) Dighe Mean | c FIE (D) Dighe Mean | E2 Upper 99% Dighe (pmol/L) | Delta (D) Dighe Upper 99% |
FIE (D) Dighe Upper 99% |
E2 Lower 99% Dighe (pmol/L) | Delta (D) Dighe Lower 99% | FIE (D) Dighe Lower 99% |
---|---|---|---|---|---|---|---|---|---|---|
−15 | 54.9 | 202 | 275 | 128 | ||||||
−14 | 53.9 | 198 | −0.02 | 253 | −0.080 | 143 | 0.117 | |||
−13 | 65 | 239 | 0.207 | ind0.41 | 319 | 0.261 | ind2.087 | 154 | 0.077 | 0.901 |
−12 | 57.9 | 213 | −0.109 | ind2.253 | 261 | −0.182 | ind4.743 | 165 | 0.071 | 0.549 |
−11 | 56.8 | 209 | −0.019 | 0.204 | 246 | −0.057 | −1.045 | 176 | 0.067 | 0.476 |
−10 | 62 | 228 | 0.091 | ind0.171 | 275 | 0.118 | ind0.678 | 180 | 0.023 | 0.152 |
−9 | 66.9 | 246 | 0.079 | 0.718 | 301 | 0.095 | 1.115 | 191 | 0.061 | 0.139 |
−8 | 74.8 | 275 | 0.118 | 0.931 | 330 | 0.096 | 0.911 | 224 | 0.173 | 1.056 |
−7 | 80.8 | 297 | 0.08 | 0.943 | 352 | 0.067 | 0.642 | 242 | 0.080 | 1.388 |
−6 | 91.9 | 338 | 0.138 | 1.104 | 400 | 0.136 | 0.909 | 279 | 0.153 | 1.229 |
−5 | 114.8 | 422 | 0.249 | 3.431 | 503 | 0.258 | 3.511 | 341 | 0.222 | 3.398 |
−4 | 136.8 | 503 | 0.192 | 4.77 | 591 | 0.175 | 4.505 | 411 | 0.205 | 4.562 |
−3 | 182.8 | 672 | 0.336 | 6.449 | 786 | 0.330 | 5.772 | 554 | 0.348 | 7.142 |
−2 | 236.6 | 870 | 0.295 | 9.9 | 1013 | 0.289 | 9.529 | 731 | 0.319 | 11.116 |
−1 | 303.6 | 1116 | 0.283 | 8.331 | 1325 | 0.308 | 8.895 | 907 | 0.241 | 7.692 |
0 | 251.6 | 925 | −0.171 | ind4.839 | 1068 | −0.194 | ind5.974 | 778 | −0.142 | ind3.424 |
1 | 130.8 | 481 | −0.48 | −8.215 | 613 | −0.426 | −8.263 | 352 | −0.548 | −7.788 |
2 | 117.8 | 433 | −0.1 | −4.79 | 532 | −0.132 | −5.629 | 334 | −0.051 | −2.800 |
3 | 133.8 | 492 | 0.136 | ind1.36 | 595 | 0.118 | ind1.565 | 385 | 0.153 | ind0.781 |
4 | 157.8 | 580 | 0.179 | 2.437 | 697 | 0.171 | 2.030 | 463 | 0.203 | 3.094 |
5 | 157.8 | 580 | 0 | 0 | 701 | 0.006 | 0.098 | 459 | −0.009 | ind0.175 |
6 | 161.8 | 595 | 0.026 | 0 | 716 | 0.021 | 0.012 | 474 | 0.033 | ind0.028 |
7 | 164.8 | 606 | 0.018 | 0.048 | 720 | 0.006 | 0.012 | 496 | 0.046 | 0.152 |
a Day-specific mean, upper 99% CI limit, lower 99% CI limit reference range serum E2 levels from Dighe et al. [18]. Days of the cycle are indexed to. Day 0, day of serum LH peak. b Delta (D) is calculated for day, D by: [E2 on day, D − E2 on day, D-1]/E2 on day, D-1 and for day, D-1 by: [E2 on Day, D-1 − E2 on day, D-2]/E2 on day, D-2. c The magnitude of FIE on day, D, is FIE(D) and is calculated by: ((Delta(D) × (Delta(D-1) × 100). The sign of FIE(D) is +, −, or indeterminate (written as in d) and is assigned as follows: +Delta(D) × +Delta(D-1) is +; −Delta(D) × −Delta(D-1) is −; and −Delta(D) × +Delta(D-1) or +Delta(D) × −Delta(D-1) is ind.