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. 2020 Oct 22;56(11):555. doi: 10.3390/medicina56110555

Table 1.

Delta and fertility indicator equation (FIE) values for day of cycle, D, from Dighe et al., data.

Day of Cycle a Mean E2 Dighe (pg/mL) Mean E2 Dighe (pmol/L) b Delta (D) Dighe Mean c FIE (D) Dighe Mean E2 Upper 99% Dighe (pmol/L) Delta (D) Dighe
Upper 99%
FIE (D)
Dighe Upper 99%
E2 Lower 99% Dighe (pmol/L) Delta (D) Dighe Lower 99% FIE (D) Dighe Lower 99%
−15 54.9 202 275 128
−14 53.9 198 −0.02 253 −0.080 143 0.117
−13 65 239 0.207 ind0.41 319 0.261 ind2.087 154 0.077 0.901
−12 57.9 213 −0.109 ind2.253 261 −0.182 ind4.743 165 0.071 0.549
−11 56.8 209 −0.019 0.204 246 −0.057 −1.045 176 0.067 0.476
−10 62 228 0.091 ind0.171 275 0.118 ind0.678 180 0.023 0.152
−9 66.9 246 0.079 0.718 301 0.095 1.115 191 0.061 0.139
−8 74.8 275 0.118 0.931 330 0.096 0.911 224 0.173 1.056
−7 80.8 297 0.08 0.943 352 0.067 0.642 242 0.080 1.388
−6 91.9 338 0.138 1.104 400 0.136 0.909 279 0.153 1.229
−5 114.8 422 0.249 3.431 503 0.258 3.511 341 0.222 3.398
−4 136.8 503 0.192 4.77 591 0.175 4.505 411 0.205 4.562
−3 182.8 672 0.336 6.449 786 0.330 5.772 554 0.348 7.142
−2 236.6 870 0.295 9.9 1013 0.289 9.529 731 0.319 11.116
−1 303.6 1116 0.283 8.331 1325 0.308 8.895 907 0.241 7.692
0 251.6 925 −0.171 ind4.839 1068 −0.194 ind5.974 778 −0.142 ind3.424
1 130.8 481 −0.48 −8.215 613 −0.426 −8.263 352 −0.548 −7.788
2 117.8 433 −0.1 −4.79 532 −0.132 −5.629 334 −0.051 −2.800
3 133.8 492 0.136 ind1.36 595 0.118 ind1.565 385 0.153 ind0.781
4 157.8 580 0.179 2.437 697 0.171 2.030 463 0.203 3.094
5 157.8 580 0 0 701 0.006 0.098 459 −0.009 ind0.175
6 161.8 595 0.026 0 716 0.021 0.012 474 0.033 ind0.028
7 164.8 606 0.018 0.048 720 0.006 0.012 496 0.046 0.152

a Day-specific mean, upper 99% CI limit, lower 99% CI limit reference range serum E2 levels from Dighe et al. [18]. Days of the cycle are indexed to. Day 0, day of serum LH peak. b Delta (D) is calculated for day, D by: [E2 on day, D − E2 on day, D-1]/E2 on day, D-1 and for day, D-1 by: [E2 on Day, D-1 − E2 on day, D-2]/E2 on day, D-2. c The magnitude of FIE on day, D, is FIE(D) and is calculated by: ((Delta(D) × (Delta(D-1) × 100). The sign of FIE(D) is +, −, or indeterminate (written as in d) and is assigned as follows: +Delta(D) × +Delta(D-1) is +; −Delta(D) × −Delta(D-1) is −; and −Delta(D) × +Delta(D-1) or +Delta(D) × −Delta(D-1) is ind.