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. 2020 Oct 22;13(11):329. doi: 10.3390/ph13110329

Table 2.

Variables and intervals selected to perform the constrained mixture design.

Variables Code Level
Low		 Code Level
High
X1: 1,5-Pentanediol 10~20% 0.0 0.6
X2: Carbitol 10~20% 0.0 1.0
X3: Benzalkonium chloride 1.5~3% 0.0 0.6

The amounts of gemcitabine, capryol 90 and methylcellulose in formulations were fixed at 1%, 5% and 2% respectively. The total amount of three variables of X1, X2 and X3 in formulation was 32%.