FIGURE 3.

The recipient susceptibility factors that participate in exerting full toxicity of the CdiA. The CdiA toxins were classified into three different classes: the CdiAs that use BamA as outer membrane (OM) receptors are class I effector, the CdiAs that use the OmpC/F are the class II effector, and the ones that use Tsx are the class III effector. The OM, inner membrane (IM), and the cytosol proteins required for full toxicity of the CdiA are labeled in blue boxes in a square, oval, and circle, respectively. The CdiA functions in pore-forming toxins are labeled in red, tRNases are labeled in blue, 16S rRNases are labeled in yellow, DNases are labeled in purple, and the nuclease is labeled in green.