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. 2020 Nov 12;11:603652. doi: 10.3389/fmicb.2020.603652

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Copyright © 2020 Lin, Filloux and Lai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Type VI secretion system (T6SS) working model. The first step of T6SS assembly is the formation of the membrane complex (MC). The second step is the recruitment of the baseplate (BP) complex and the effector-containing complex (ECC) to the MC. The third step is the polymerization of the inner tube and the outer sheath inside the attacker cytosol. Upon trigger, the outer sheath contracts and propels the inner tube to penetrate the recipient membrane. OM, outer membrane; P, periplasm; IM, inner membrane; CP, cytoplasm.