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. 2020 Nov 12;11:603652. doi: 10.3389/fmicb.2020.603652

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Copyright © 2020 Lin, Filloux and Lai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The recipient susceptibility factors enhancing the outcome of the type VI secretion system (T6SS) attack. The T6SS attack from the recipient cell triggers a T6SS counterattack. The T4SS-mediated membrane disruption that is caused by the adhesin TraC and Pep is required for activating the T6SS attack. Lysed siblings, aggressive competitors, and the non-self-competitors also trigger a T6SS attack. The elongation factor thermo-unstable (EF-Tu) of the recipient cell may be required for Tse6 to exert full toxicity, but the mechanism remains elusive. The DsbA of the recipient cell is required to activate the Ssp2 and Ssp4 periplasmic toxins. OM, outer membrane; P, periplasm; IM, inner membrane; CP, cytoplasm.