TABLE 1.
Recipient susceptibility (RS) factors required for bacterial secretion system toxins.
| RS factor | Known or putative function of RS | Toxin | Secretion system | Toxin function |
| OM factors | ||||
| BamA | Translocator | CdiAEC93 | CDI | Putative pore-forming |
| OmpC/OmpF | Translocator | CdiAEC536 | CDI | tRNase |
| Translocator | CdiAECL | CDI | 16S rRNase | |
| Tsx, OmpT | Translocator | CdiASTEC031 | CDI | tRNase |
| PerA | Translocator | CdzC/Cdzd | Cdz | unknown |
| Periplasmic factors | ||||
| DsbA | Activator | Ssp2 | T6SS | Peptidoglycan hydrolases |
| Activator | Ssp4 | T6SS | unknown | |
| IM factors | ||||
| AcrB | Translocator/activator? | CdiAEC93 | CDI | Putative pore-forming |
| FtsH | Translocator | CdiAEC536 | CDI | tRNase |
| CdiAECL | CDI | 16S rRNase | ||
| PstG | Translocator | CdiASTECO31 | CDI | tRNase |
| Translocator | CdiANC101 | CDI | tRNase | |
| Translocator | CdiAEC3006 | CDI | tRNase | |
| YciB | Translocator | CdiAEC869 | CDI | tRNase |
| MetI | Translocator | CdiAMH813 | CDI | Nuclease |
| GltK | Translocator | CdiATT01 | CDI | Nuclease |
| RbsC | Translocator | CdiADd3937 | CDI | DNase |
| Cytosol factors | ||||
| CysK | Activator | CdiAEC536 | CDI | tRNase |
| EF-Tu/EF-Ts | Activator | CdiANC101 | CDI | tRNase |
| Activator | CdiAEC3006 | CDI | tRNase | |
| Activator | CdiAEC869 | CDI | tRNase | |
| unknown | Tse6 | T6SS | NAD(P) + Glycohydrolase | |
CDI, contact-dependent inhibition; OM, outer membrane; T6SS, type VI secretion system; IM, inner membrane; Cdz, CDI by glycine zipper protein.