Figure 2.

Phenomenological model. (A) Influence network of the simplified version of ICD: it involves three cell types: tumor cells (Tumor Cell and Dying Tumor Cell for cells that have been treated by chemotherapeutic agents, gray nodes), dendritic cells (DC for immature dendritic cells, ActDC for mature dendritic cells, MigrDC for migrating dendritic cells, and LNodeDC for dendritic cells in the lymph node, purple nodes), T cells (T Cell, and CTL for cytotoxic T lymphocyte, blue nodes). (B) Early activation of ICD markers (Note: CALR overlaps with ATP). (C) Kinetics of the cell types with ICD. (D) Kinetics of the tumor cell populations without ICD.