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. 2020 Nov 12;11:590479. doi: 10.3389/fphys.2020.590479

Figure 4.

Figure 4

Sensitivity analysis of the Extended Model. (A) Tumor size at time= 220 h vs. time= 280 h when the different parameters of the extended model were increased or decreased by 50%. Initial amount of Dendritic cells and rate of clonal expansion show the strongest effect (for WT, $InitDC= 0.1, $clonal_exp_rate= 0.05; for High DC, $InitDC= 0.15 and Low DC, $InitDC= 0.067; for Fast Clonal Exp., $clonal_exp_rate= 0.075, and for Slow Clonal Exp., $clonal_exp_rate= 0.033). (B) Kinetics of the size of the tumor cell population according to the parameters changes highlighted in (A). (C) Tumor size at time= 220 h vs. time= 280 h when the different parameters of the extended model were multiplied or divided by 5. Faster activation of IL2 and slower activation of CD80 have the strongest effect. (D) Kinetics of the size of the tumor cell population following a treatment with IL2 (IL2 treat) or a mutation of CD28 on T cells (CD28 mut), inspired by the parameters changes highlighted in (C).