Table 2.

Estimates of plasma concentration (C) values recorded for capecitabine and its metabolites at tmax (2 h) with or without high dose rabeprazole.

Ctmax (μg/mL)	T1 (4 Weeks)			T2 (8 Weeks)
	mCAP+rabe (22)	mCAP (20)	p Value	mCAP+rabe (22)	mCAP (20)	p Value
	(Mean ± Std.dev.)			(Mean ± Std.dev.)
Capecitabine	0.58 ± 0.67	0.38 ± 0.46	0.315	0.38 ± 0.64	0.41 ± 0.32	0.160
5-DFUR	1.85 ± 1.52	1.43 ± 2.01	0.168	1.41 ± 1.25	1.26 ± 0.65	0.018
5-FU	0.29 ± 0.32	0.33 ± 0.62	0.270	0.31 ± 0.30	0.26 ± 0.34	0.968

Abbreviations: mCAP: metronomic capecitabine; rabe: rabeprazole; 5′-DFUR: 5‘-deoxy-5,-fluorouridine; 5-FU: 5-fluoruracil.