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Kinetic parameters of phloretin hydroxylation via human liver microsomes (HLMs), CYP3A4, and CYP 2C19.
| Enzymes | kcat (min−1 ) | Km (μM) | kcat/Km (min−1μM−1) |
|---|---|---|---|
| HLMs | 0.094 ± 0.006 | 120 ± 36 | 0.00083 ± 0.00025 |
| CYP3A4 | 3.1 ± 2.9 | 63 ± 11 | 0.049 ± 0.023 |
| CYP2C19 | 5.8 ± 0.6 | 208 ± 50 | 0.028 ± 0.007 |
