Table 3.

Adonis analysis assessing association between variation in gut microbiota at OTU level and host characteristics using Bray-Curtis distance and Jaccard distance.

OTUs Level (relative abundance rarefied)
Variable	D_Bray			D_Jaccard
	F. modela	R2b	p-value	F. model	R2	p-value
IC/Non IC	1.03	0.01	0.41	1.18	0.011	0.16
C. difficile	1.28	0.013	0.082	2.34	0.022	0.001**
Gender	1.56	0.015	0.039*	1.22	0.012	0.12
Antibiotics (previous 3 mos.)	0.76	0.007	0.8	1.18	0.011	0.17
Current antibiotics	2.21	0.02	0.002**	3.44	0.033	0.001**
Diarrhea	1.89	0.018	0.013*	1.59	0.015	0.016*
Hospitalization	0.95	0.009	0.49	1.4	0.014	0.038*
PPI	1.95	0.019	0.01*	2.12	0.02	0.002**

^aThe pseudo F ratio compares the total sum of squared dissimilarities among subjects between groups to that of subjects within group; large F-ratios indicate strong group separation.

^bR2 value indicates the percentage of variation in the group dissimilarities explained by the variable.

^*P ≤ 0.05;

^**P ≤ 0.01.