Table 1.

Summary of objectives, samples, and aims of the PI-POC^a study.

Objective	Aim	Specimen analyses	Specimen utilized
I	Validating a novel nucleic acid-based multi-POCb method developed for the identification of CSFc pathogens.	Sweden	CSF and cases
II	Evaluating the clinical utilization of a commercially available multiplex MEd PCR panel in a low-income setting.	Uganda	CSF and cases
III	Updating current etiology of pediatric CNSe infections in Mbarara and comparing it to the pre-pneumococcal conjugate vaccine era.	Uganda/Sweden	CSF and cases
IV	Validating MxAf as a blood biomarker for differentiation of viral/nonviral cause of CNS infection.	Sweden	Plasma and cases and controls
V	Comparing proteomic characteristics of severe/nonsevere childhood infection and identification of novel biomarkers for severe pediatric infections.	Sweden	CSF, cases, plasma, and cases and controls
VI	Identifying mechanisms of virulence traits of Neisseria meningitidis isolated from pediatric patients.	Sweden	Nasopharyngeal swabs and cases and controls

^aPI-POC: Pediatric Infection-Point-of-Care (trial).

^bPOC: point of care.

^cCSF: cerebrospinal fluid.

^dME: meningitis/encephalitis.

^eCNS: central nervous system.

^fMxA: Myxovirus resistance protein A.