Table 2.
Summary of samples and analyses in Uganda and Sweden.a
| Specimens (type and tests) | Inclusion (Day 0) | Day 3 | Clinical analyses (when/where) | Type of research analyses (when/where) | |
| Cases |
|
|
|
|
|
|
|
Blood: Hematology, biochemistry, HIV serology (and confirmation), malaria RDTb, culture, plasma biobank | 6 mL | 1-2 mL | Routine clinical analyses (same day at the Epicentre Laboratory). | Proteomics analyses for profiling of biomarkers including MxAe (later at the SciLifeLabf). |
|
|
CSFc: Biochemistry, microscopy and cytology, culture, MEd-PCR panel, PCR, biobank | 2 mL | — | Routine clinical analyses including ME-PCR panel (same day at the Epicentre Laboratory). | Proteomics analyses for profiling of biomarkers including MxA (later at the SciLifeLab). |
|
|
Nasopharyngeal swabs: Biobank | 1 swab | — | — | Typing of bacteria and bacterial whole-genome sequencing (later at the Karolinska Institutet and SciLifeLab). |
| Controls |
|
|
|
|
|
|
|
Blood: Hematology, HIV serology (and confirmation), malaria RDT, biobank | 1-2 mL | — | Routine clinical analyses (same day at the Epicentre Laboratory). | Proteomics analyses for profiling of biomarkers including MxA (later at the SciLifeLab). |
|
|
Nasopharyngeal swabs: Biobank | 1 swab | — | — | Typing of bacteria and bacterial whole-genome sequencing (later at the Karolinska Institutet and SciLifeLab). |
aAdditional testing for clinical care, such as TB GeneXpert or TB ZN, was performed according to clinical needs and at the discretion of the medical officer.
bRDT: rapid diagnostic test
cCSF: cerebrospinal fluid.
dME: meningitis/encephalitis.
eMxA: Myxovirus resistance protein A
fSciLifeLab: Science for Life Laboratory.