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. 2020 Nov 4;9(11):e21430. doi: 10.2196/21430

Table 2.

Summary of samples and analyses in Uganda and Sweden.a

Specimens (type and tests) Inclusion (Day 0) Day 3 Clinical analyses (when/where) Type of research analyses (when/where)
Cases




Blood: Hematology, biochemistry, HIV serology (and confirmation), malaria RDTb, culture, plasma biobank 6 mL 1-2 mL Routine clinical analyses (same day at the Epicentre Laboratory). Proteomics analyses for profiling of biomarkers including MxAe (later at the SciLifeLabf).

CSFc: Biochemistry, microscopy and cytology, culture, MEd-PCR panel, PCR, biobank 2 mL Routine clinical analyses including ME-PCR panel (same day at the Epicentre Laboratory). Proteomics analyses for profiling of biomarkers including MxA (later at the SciLifeLab).

Nasopharyngeal swabs: Biobank 1 swab Typing of bacteria and bacterial whole-genome sequencing (later at the Karolinska Institutet and SciLifeLab).
Controls




Blood: Hematology, HIV serology (and confirmation), malaria RDT, biobank 1-2 mL Routine clinical analyses (same day at the Epicentre Laboratory). Proteomics analyses for profiling of biomarkers including MxA (later at the SciLifeLab).

Nasopharyngeal swabs: Biobank 1 swab Typing of bacteria and bacterial whole-genome sequencing (later at the Karolinska Institutet and SciLifeLab).

aAdditional testing for clinical care, such as TB GeneXpert or TB ZN, was performed according to clinical needs and at the discretion of the medical officer.

bRDT: rapid diagnostic test

cCSF: cerebrospinal fluid.

dME: meningitis/encephalitis.

eMxA: Myxovirus resistance protein A

fSciLifeLab: Science for Life Laboratory.