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Archaeal DNA repair pathways follow similar generalized steps: (i) Recognition of DNA damage by pathway-specific enzymes. (ii) Initiation of repair by conversion of DNA damage into appropriate and repairable substrate. (iii) Conclusion of repair by resynthesis of damaged DNA from a complementary undamaged strand, degradation of damaged strand by flap endonuclease of intrinsic DNA polymerase exonuclease activity, and nick ligation by DNA ligase.
