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Eukaryotic global genomic nucleotide excision repair. DNA damages which distort the DNA double helix are recognized by XPC, which recruits the damage recognition XPA and TFIIH complex. Components of the TFIIH complex melt strands of DNA around a verified DNA lesion, allowing cuts of the damaged strand by XPG and XPF. The TFIIH complex uses helicase activity to “excise” the damaged strand, allowing conclusion of repair by DNA polymerase and DNA ligase I.
