Table 5.

Literature review of the main identified bioactive compounds in the Teucrium species and the solvent used.

Teucrium Species/Origin	Solvent Used	Main Identified Compounds	References
T. polium L. Serbia	Methanol	Phenolic acids (×10−4 µg/mL extract µg/mL extract):gallic acid (8.1 ± 0.2), vanillic acid (2.1 ± 0.3), caffeic acid (1.7 ± 0.2), chlorogenic acid (90.00 ± 0.2), and p-coumaric acid (30.0 ± 0.6). Flavonoids (×10−4 µg/mL extract µg/mL extract):catechin (235.0 ± 0.5), rutin (77.0 ± 0.1), myricetin (55.0 ± 0.1), luteolin (22.0 ± 0.6), quercetin (24.0 ± 0.4), and apigenin (157.0 ± 0.3).	[35]
T. polium L. Greece	Methanol/Water 62.5%	Phenolic compounds (mg/100g dry sample): tyrosol (0.42 ± 0.01), caffeic acid (0.65 ± 0.01), ferulic acid (0.95 ± 0.02), and luteolin (0.48 ± 0.01)	[36]
		o-Hydroxybenzoic acid, hydroxytyrosol, p-Hydroxybenzoic acid, vanillic acid, gentisic acid, ferulic acid, caffeic acid, 3-Nitro-phthalic acid, and quercetin.
T. polium L. Egypt	Dichloromethane–methanol (1:1; v/v)	(1R,4S,10R) 10,11-dimethyl-dicyclohex-5 (6)-en-1,4-diol-7-one and (R)-mandelonitrile-b-laminaribioside.	[37]
T. polium L Italy	Methanol	Poliumoside B, poliumoside, teucardosid, 8-O-acetylharpagid, luteolin7-O-rutinoside, luteolin7-O-neohesperidoside, luteolin7-O-glucosied, luteolin 4′-O-glucoside, teulamifin, and teusalvin C.	[38]
T. polium L. R. Macedonia	Methanol	Hydroxycinnamic acid derivatives (2 compounds), phenylethanoid glycosides (12 compounds), flavonoid glycosides (11 compounds) and flavonoid aglycones (6 compounds).	[40]
T. polium L. Italy	Methanol	Poliumoside, apigenin, luteolin, montanin D, montanin E, teubutilin A, teuchamecrin C, teulamifin B, teupolin VI, teupolin VII, teupolin VIII, teupolin IX, teupolin X, teupolin XI, and teupolin XII.	[42]
T. polium L. Iran	Methanol	Rutin, apigenin, (3′, 6 dimethoxy apigenin, and 4′,7 dimethoxy apigenin.	[43]
T. polium L. Europe	Ethanol 70%	Rutin, apigenin, apigenin-4, 7-dimethylether, cirsimaritin, cirsiliol, luteolin, 6-hydroxyluteolin, luteolin-7-O-glucoside, salvigenin, apigenin 7-glucoside, eupatorin, apigenin-5 galloylglucoside, 3′,6- dimethoxy apigenin, 4′,7-dimethoxy apigenin, and salvigenin.	[44]
T. polium L. Egypt	Dichloromethane–methanol (1:1; v/v)	Sesquiterpenes: 4β,5α-epoxy-7αH-germacr-10(14)-en-6β-ol-1-one, 4β,5α-epoxy-7αH-germacr-10(14)-en,1β-hydroperoxyl,6β-ol, 4β,5β-epoxy-7αH-germacr-10(14)-en,1β-hydroperoxyl,6β-ol 4α,5β-epoxy-7αH-germacr-10(14)-en,1β-hydroperoxyl,6α-ol, 10a,1b;4b,5a-diepoxy-7aH-germacrm-6-ol, teucladiol, 4b,6b-dihydroxy-1a,5b(H)-guai-9-ene, oplopanone, oxyphyllenodiol A, eudesm-3-ene-1,6-diol, rel1b,3a,6b-trihydroxyeudesm-4-ene, arteincultone. Flavonoids: 7,40 -O-dimethylscutellar-ein(5,6-dihydroxy-7,40 -dimethoxyflavone) and salvigenin. Glycosides: teucardoside and poliumoside.	[90]
T. polium L. Saudi Arabia	Methanol	Larixol acetate, cepharanthine, Bis (2-hydroxypropyl) amine, 9-amino-nonanoic acid, 10-amino-decanoic acid, CMP-N-acetylneuraminic acid, selinidin, dihydrosamidin, triptonide, 10S,11R-Epoxy-punaglandin 4, rhoifolin, 3-hydroxy-3′,4′- dimethoxyflavone, sericetin diacetate, troxerutin, 1-dodecanoyl-sn-glycerol, harpagoside, koparin 2′-methyl ether, isotectorigenin, 7-methyl ether, 10-hydroxyloganin, 7-epiloganin tetraacetate, deoxyloganin tetraacetate, 8-epiiridodial glucoside tetraacetate, 16-hydroxy-4-carboxyretinoic acid, carapin-8 (9)-ene, khayanthone, 13R-hydroxy-9E,11Z octadecadienoic acid, b-D-glucopyranoside uronic acid, 6-(3-oxobutyl)-2-naphthalenyl, 16alpha,17beta-Estriol 3-(beta-D-glucuronide), and valtratum.	This Study