Table 3.
The influence of alginate concentration on the properties of its nanoparticles.
| Alginate Concentration (% w/v) | Preparation Method | Drug | Mean Particle Size (nm) | Polydispersity Index (%) | Zeta Potential (mV) | Encapsulation Efficiency (%) | Reference |
|---|---|---|---|---|---|---|---|
| 3 | Emulsification/external gelation | Protein | 700 | - | - | 47 | [139] |
| 5 | 900 | 51 | |||||
| 0.50 | Emulsification/internal gelation | Peppermint | 512 | - | - | Increase | [141] |
| 1 | 4303 | ||||||
| 0.05 | Ionic gelation/complexation | Crocin | Increase | - | - | Increase | [133] |
| 0.30 | |||||||
| 0.1 | Ionic gelation/complexation | Timolol Maleate | 473.1 | 0.37 ± 0.05 | - | 33.71 ± 4.7 | [144] |
| 0.5 | 489.3 | 0.51 ± 0.1 | 39.01 ± 2.8 | ||||
| 0.03 | Ionic gelation/complexation | Nisaplin® | 86 | - | −33.2 | 35.6 | [145] |
| 0.07 | 204 | −38.7 | 30.5 | ||||
| 0.1 | Emulsification/external gelation | Doxorubicin | 39.2 | 0.19 | - | 92.2 | [148] |
| 0.2 | 149.6 | 0.38 | 98.4 | ||||
| 0.01 | Ionotropic pre-gelation/complexation | Insulin | Increase | Increase | - | - | [146] |
| 0.1 | |||||||
| 0.6 | Ionotropic gelation | Curcumin | 105 | - | 150 ± 1.15 | 94 ± 4.2 | [147] |
| 0.8 | 107 | 200 ± 2.15 | 92 ± 3.6 | ||||
| 1.0 | Electrospray | - | 315.9 ± 37.5 | 0.24 ± 0.10 | - | - | [115] |
| 2.0 | 348.2 ± 63.9 | 0.28 ± 0.03 |
PDI: polydispersity index; EE: encapsulation efficiency; Ref: references.