Table 5.
The influence of CaCl2 concentration on alginate nanoparticles.
| CaCl2 Concentration (% w/v) | Preparation Method | Drug | Particle Size (nm) | Polydispersity Index | Zeta Potential (mV) | Encapsulation Efficiency (%) | Reference |
|---|---|---|---|---|---|---|---|
| 0.05 | Emulsification/internal gelation | Vegetable Oils | 361 | - | - | 5.10 | [141] |
| 0.15 | 140 | 6.66 | |||||
| 0.05 | Ionic gelation/complexation | Timolol Maleate | 473 | 0.37 | - | 33.71 | [144] |
| 0.25 | 200 | 0.27 | 35.23 | ||||
| 3.0 | Ionotropic pre-gelation/complexation | Metronidazole | Decrease | - | Less negative | - | [152] |
| 6.0 | |||||||
| 0.5 | Ionotropic gelation/complexation | Insulin | Increase | Increase | - | - | [146] |
| 3.0 |