Table 6.
The influence of pH on the prepared alginate nanoparticles.
| Drug | Preparation Method | Formulation Composition | pH | Particle Size (nm) | Encapsulation Efficiency (%) | Zeta Potential (mV) | Reference |
|---|---|---|---|---|---|---|---|
| Crocin | Ionic gelation | Alginate 0.025% w/v Chitosan 0.04% w/v |
5.16 4.74 |
341 268 |
30.7 33.1 |
- | [133] |
| Insulin | Ionotropic pre-gelation | Alginate Chitosan Cationic β-cyclodextrin |
4.90 | 150.82 | 93.2 | - | [146] |
| Blank/ε-polylysine | Ionic gelation | Alginate 0.1% w/v Chitosan 0.1% w/v |
5.14 | 276.38 | 54.18 | −33.7 | [90] |
| Blank/doxorubicin | Ionic gelation | Alginate 0.3% w/v Chitosan 0.075% w/v |
5.30 | 352 | 90 | −32 | [89] |
| Curcum | Layer-by-layer | Chitosan layer 200 mL Alginate layer 150 mL |
3.0 5.0 7.0 |
- | - | +1 −30 −27 |
[92] |
| Curcumin diethyl diglutarate | o/w Emulsification and ionotropic gelation | Alginate 0.6 mg/mL/pH = 4.9 Chitosan/pH = 4.6 Pluronic®F-127 (surfactant) |
- | 215 | 85 | −24.1 | [177] |