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. 2020 Oct 23;12(11):3091. doi: 10.3390/cancers12113091

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic description of the bidirectional calculation method for the association between mRNA expression and RNAi efficacy for a given gene in the cell line panel. (A) Distribution of cell lines by mRNA expression vs. RNAi efficacy for a given gene. Predictivity and descriptivity were calculated after cell lines were grouped based on median mRNA expression levels and RNAi efficacy. (B) An example plot of the predictivity and descriptivity scores of over 12,000 genes derived from the calculation method in (A). Colored circles represent genes with statistical significance (p-value < 0.01) for both predictivity and descriptivity.