Figure 7.

Bidirectional predictivity and descriptivity analyses of 19,079 genes in samples from 171 COAD TCGA patients. mRNA expression of a gene and the survival record of the patient from which the sample was obtained were used for bidirectional calculations. (A) Predictivity vs. descriptivity between mRNA expression and disease-free survival in days are plotted. Genes showing positive or negative association with a predictivity p-value < 0.01 and descriptivity p-value < 0.05 were selected. Among 322 hit genes, KIF26A and ZIC2 are common among shRNA hit genes and showed positive and negative correlations in shRNA analysis, respectively. (B,C) Graph of disease-free survival according to high and low gene expression of KIF26A and ZIC2, respectively. (D,E) mRNA expression vs. shKIF26A/shZIC2 efficacy in colon cancer cell lines.