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. 2020 Oct 23;8(11):1645. doi: 10.3390/microorganisms8111645

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Seroconversion and dynamics of antibody isotypes against F. tularensis in patients treated early with antibiotics. Sera from nine patients diagnosed with acute tularemia were analyzed by ELISA. For sampling time points 1–3 ((A) sampled on 4th November 2018, one week after exposure; (B) sampled on 8th November 2018, two weeks after exposure; (C) sampled on 14th November 2018, threeweeks after exposure), sera from all nine patients were available. For sampling time point 4 ((D) sampled in April/May 2019, 21 weeks after exposure), only sera from six patients were available. Exposure date was 27th October 2018 and patients were admitted with clinical signs to the hospital on 1st November 2018. The validated diagnostic cut-offs of this assay are: positive OD > 0.6, borderline OD 0.25–0.6, negative < 0.25.