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. 2020 Oct 23;12(11):3102. doi: 10.3390/cancers12113102

Figure 1.

Figure 1

The γtubulin meshwork interacts with cellular components that affect the nuclear architecture. The meshwork is composed of centrosomes, γtubules, and γstrings. A γtubule consists of a γtubulin ring complex (γTURC), and pericentrin and can lie close to the outer nuclear membrane (ONM). Hypothetical representation of how γstrings connect cytosolic organelles (centrosome, mitochondria) and cytoskeletal elements (MTs, actin, and γtubules) with the nuclear compartment [14,17,18]. In the nucleus, γtubulin interacts with laminB (lamina) [17], the nucleoporin embryonic large molecule derived from yolk sac (ELYS), which is part of the nuclear pore complex (NPC) [99], the inner nuclear membrane (INM) protein Samp1 [104], the chromatin associated proteins Rad51 [106] and C53 [100], and the transcription factor E2 promoter binding factor (E2F)1 [88]. The black arrows indicate the positions of the fibrillar center (FC), granular center (GC), and dense fibrillar component (DFC) in the nucleolus. The magenta lines indicate inhibition.