Table 1. Immunologic workup of the SLP76-deficient patient.
| Patient | Normal rangea | |
|---|---|---|
| CBC (cells/ml × 103) | ||
| WBC | 12.5 | 5.2–11 |
| Neutrophils | 5.6 | 1–8.5 |
| Monocytes | 0.2 | 0.2–1 |
| Lymphocytes | 8.2 | 3.4–7.6 |
| Eosinophils | 0.01 | 0–0.7 |
| Hemoglobin (g/dl) | 9.6 | 11–14 |
| Platelets | 243 | 150–400 |
| Lymphocyte subsets (cells/ml × 103) | ||
| T cells (CD3+) | 7.6 | 2.5–5.5 |
| T helper cell (CD4+) | 0.65 | 1.6–4 |
| Cytotoxic T cell (CD8+) | 6.65 | 0.6–1.7 |
| Double negative (CD4−CD8−αβ+; % of WBC) | 0.4% | <1% |
| αβ TCR | 57% | 26–100% |
| γδ TCR | 2% | 1–38% |
| Regulatory T cell (CD4+CD25+FOXP3+) | 4% | >5% |
| B cells (CD45+CD19+) | 0.36 (6%) | 0.05–0.3 (5–25%) |
| NK (CD16+CD56+) | 36% | 6–30% |
| TREC (copies per 0.5 mg DNA) | 36 | >400 |
| Serum Ig (mg/dl) | ||
| IgA | 36 | 38-222 |
| IgM | 434 | 56-208 |
| IgG | 1,220 | 590-1,430 |
CBC, complete blood count; TREC, TCR excision circles; WBC, white blood cell.
aHealthy donors, age 1–2 yr, with percentages/counts presented as median (10th and 90th percentiles).