Table 3. Associations between the consumption volume of 11 antibiotics and the cumulative incidence of 3GC- and/or carbapenem-resistant infections in 357 wards.
| Predicted percent change in incidence (95% CI) per doubling of consumption volume | |||
|---|---|---|---|
| Antibiotics | 3GCR incidence model | CR incidence model | 3GCR or CR incidence model |
| TZP | 5.9 (2.9, 9.0) | 10.3 (5.0, 16.0) | 6.1 (3.1, 9.2) |
| CTX/CRO | 4.8 (1.5, 8.2) | 1.8 (-3.7, 7.6) | 4.6 (1.4, 8.0) |
| AMX | 2.7 (-1.5, 7.0) | 3.6 (-3.4, 11.2) | 2.7 (-1.4, 7.0) |
| CTZ/FEP | 1.7 (-1.0, 4.5) | 3.3 (-1.5, 8.3) | 1.6 (-1.1, 4.4) |
| IPM/MEM | 1.4 (-1.8, 4.7) | 5.1 (-0.6, 11.1) | 1.5 (-1.6, 4.8) |
| FQ | 0.5 (-1.9, 2.9) | −1.2 (-5.2, 3.0) | 0.4 (-1.9, 2.8) |
| OXA | −0.6 (-2.2, 1.1) | −2.0 (-4.6, 0.7) | −0.6 (-2.2, 1.0) |
| AMIN | −1.7 (-4.3, 0.9) | −1.1 (-5.4, 3.6) | −1.7 (-4.3, 0.9) |
| VAN/TEC | −2.3 (-4.9, 0.4) | −3.8 (-8.3, 0.9) | −2.3 (-4.9, 0.5) |
| 1GC/2GC | −2.1 (-4.0,–0.2) | −2.3 (-5.4, 1.0) | −2.1 (-4.0,–0.3) |
| AMC | −4.1 (-7.0,–1.1) | −5.8 (-10.6,–0.7) | −4.1 (-7.0,–1.1) |
NOTE. a Percent change was estimated from multivariable quasi-Poisson regression models that included the connectivity and the incidence control covariates (see Materials and methods). 3GCR, 3rd-generation cephalosporins-resistant infections; CR, carbapenem-resistant infections. Acronyms of antibiotics are listed in Table 2.