Table 1. TOP five candidates for putative deubiquitinases (DUBs) from Legionella effector proteins.

Legionella proteins		Target proteins
Name	Aligned region	Name	Aligned region	Probability (%)	Identities (%)	PDB ID_Chain
Lpg1621	195–274	Viral OTU (CC hemorrhagic fever virus)	69–157	92.59	16	3PHU_B
	195–274	Human OTUD2	63–140	92.52	17	4BOQ_A
	195–279	Human OTUD3	59–142	92.40	13	4BOU_A
	193–278	Human OTUD5	100–183	91.18	21	3PFY_A
	192–279	Viral OTU (Farallon virus)	88–183	91.08	16	6D × 5_B
Lpg2529	1–310	Viral OTU (Erve virus)	17–157	96.24	18	5JZE_A
	7–310	Viral OTU (Dera Ghazi Khan orthonairovirus)	25–156	96.15	18	6D × 2_B
	20–310	Human Otubain1	50–234	96.02	13	2ZFY_A
	20–310	Human Otubain2	50–233	95.84	13	4FJV_C
	7–310	Viral OTU (Taggert virus)	23–156	95.71	13	6D × 3_D
Lpg2411	110–216	Yeast UCH8	152–259	37.94	11	3MHS_A
	183–272	EntA-im (Enterococcus faecium)	7–89	37.06	15	2BL8_B
	33–94	Uncharacterized protein (Corynebacterium diphtheriae)	7–72	36.65	21	3KDQ_D
	120–212	PG0816 (Porphyromonas gingivalis)	53–139	35.31	16	2APL_A
	104–114	PSII reaction center protein K (Cyanidium caldarium)	2–12	32.96	36	4YUU_X2
Lpg2907	117–384	AvrA (Salmonella typhimurium)	59–299	100	11	6BE0_A
	158–398	PopP2 (Arabidopsis thaliana)	99–339	99.93	13	5W3X_C
	115–390	HopZ1a (Pseudomonas syringae)	54–342	99.88	10	5KLP_C
	118–275	XopD (Xanthomonas campestris)	1–148	95.53	11	2OIX_A
	95–276	Human SENP1	2–177	95.21	16	2G4D_A

Values are obtained from the HHpred server (MPI Bioinformatics Toolkit).