FIG 4.

SARS-CoV-2 coevolving and independent SNVs. (A) SNV frequencies are plotted by their positions in the SARS-CoV-2 genome. The relative positions of common SNVs (>0.5%) and 9 representative coevolving variant (CEV) groups and amino acid consequences are shown. (B) Nine representative CEV groups showing different genome frequencies. Three CEV groups involved UTR variants (shown in red). syn, synonymous; RdRP, RNA-dependent RNA polymerase; exoN, 3′-to-5′ exonuclease; endoU, endoRNase; methylT, 2′-O-ribose methyltransferase; n.a., not applicable. *, this SNV was associated with other SNVs in CEVg5 in the 29 May 2020 data set but was no longer associated in the 5 October 2020 data set.