Table 5.
Cardiac data—before and after treatment
| Patient 1 | Patient 2 | Patient 3 | ||||
|---|---|---|---|---|---|---|
| Baseline | After OLT | Baseline | After BVZ | Baseline | After BVZ | |
| ECG | ||||||
| Rhythm | AFLI | AFLI | SR | SR | AFLI | AFLI |
| Heart rate (bpm) | 77 | 90 | 95 | 83 | 86 | 74 |
| Echocardiogram | ||||||
| LV size | Normal | Normal | Normal | Normal | Normal | Normal |
| LVEF (%) | 60 | 50 | 60 | 60 | 60 | 60 |
| Left heart valve disease | No | No | No | No | No | No |
| RV size | Normal | Normal | Slight dilatation | Slight dilatation | Moderate dilatation | Moderate dilatation |
| TAPSE (mm) | 34 | 14 | 31 | 24 | 17 | 20 |
| TR size | Mild | Mild | Moderate | Moderate | Moderate | Moderate |
| TRG (mmHg) | 43 | 30 | 36 | 41 | 65 | 39 |
| RHC | ||||||
| PCWP (mmHg) | 18 | NA | 18 | 21 | 22 | 14 |
| PAP, systolic (mmHg) | 43 | NA | 52 | 60 | 78 | 51 |
| PAP, diastolic (mmHg) | 23 | NA | 21 | 21 | 32 | 22 |
| PAP, mean (mmHg) | 32 | NA | 38 | 40 | 48 | 32 |
| RVP, systolic (mmHg) | 42 | NA | 48 | 60 | 78 | 51 |
| RVP, diastolic (mmHg) | 10 | NA | 11 | 15 | 20 | 9 |
| RAP (mmHg) | 13 | NA | 12 | 12 | 18 | 9 |
| Cardiac output (l/min) | 10.2 | 6.5a | 8.5 | 6.2 | 7.8 | 6.4 |
| Cardiac index (l/min/m2) | 6.6 | 4.5a | 5.4 | 4.4 | 5.3 | 4.3 |
| SVO2 (%) | 90 | NA | 86 | 81 | 77 | 85 |
| PVR (WU) | 1.4 | NA | 2.4 | 3.1 | 3.7 | 2.8 |
aPerioperative
OLT orthotopic liver transplantation, BVZ bevacizumab, AFLI atrial fibrillation, SR sinus rhythm, bpm beats per minute, LV left ventricular, LVEF left ventricular ejection fraction, RV right ventricular, TAPSE tricuspid annular plane systolic excursion, TR tricuspid valve regurgitation, TRG max tricuspid regurgitation gradient, RHC right heart catheterization, PCWP pulmonary wedge pressure, NA not available, PAP pulmonary arterial pressure, RVP right ventricular pressure, RA right atrium pressure, SVO2 pulmonic arterial oxygen saturation, PVR pulmonary vascular resistance, WU wood units