Table 3.
Major clinical manifestations of nervous system damage caused by EBV
| Symptoms (Number of cases) | Encephalitis/meningoencephalitis (n = 64) | Myelitis (n = 2) | EBV-HLH (n = 4) | NS-PTLD (n = 1) | ADEM (n = 3) | GBS (n = 15) |
|---|---|---|---|---|---|---|
| Fever | 60 | 2 | 4 | 1 | 3 | 4 |
| Intracranial hypertension | 37 | 0 | 1 | 0 | 1 | 2 |
| Drowsy-lethargy | 7 | 0 | 1 | 0 | 1 | 2 |
| Coma | 15 | 0 | 0 | 0 | 2 | 0 |
| Convulsions (not including SE) | 21 | 0 | 0 | 0 | 0 | 0 |
| Status epilepticus | 8 | 0 | 0 | 1 | 2 | 0 |
| Mental symptoms | 4 | 0 | 0 | 0 | 0 | 0 |
| Central respiratory failure | 8 | 0 | 1 | 0 | 1 | 0 |
| Peripheral respiratory failure | 1 | 1 | 0 | 0 | 0 | 3 |
| Ataxia | 3 | 0 | 0 | 1 | 1 | 0 |
| Facial nerve | 5 | 0 | 0 | 0 | 2 | 1 |
| Oculomotor nerve | 0 | 0 | 0 | 0 | 1 | 2 |
| Bulbar paralysis | 0 | 0 | 0 | 0 | 0 | 10 |
| Pyramidal tract sign | 24 | 2 | 0 | 0 | 1 | 0 |
| Meningeal irritation sign | 24 | 1 | 0 | 0 | 3 | 9 |
| Increased muscle tension | 13 | 1 | 0 | 0 | 2 | 0 |
| Decreased muscle tension | 7 | 2 | 0 | 0 | 2 | 9 |
| Decreased muscle strength | 9 | 2 | 0 | 0 | 2 | 15 |
| Defecation disorder | 0 | 1 | 0 | 0 | 0 | 3 |
| Urination disorder | 1 | 0 | 0 | 0 | 1 | 4 |
| Nerve root pain | 0 | 1 | 0 | 0 | 0 | 2 |
SE Status epilepticus, EBV-HLH EBV-hemophagocytic lymphohistiocytosis, NS-PTLD NS-post-transplant lymphoproliferative disorder, ADEM acute disseminated encephalomyelitis, GBS Guillain–Barré Syndrome