Table 1.
Group Composition, Age, Body Mass, and Occurrence of Aortic Dissection in FVB Mice
| n | Age (Weeks) | Body Mass (g) | Aortic Dissection |
||
|---|---|---|---|---|---|
| % Dissected | p Value | ||||
| Blank | 15 | 7.1 ± 0.0 | 18.8 ± 0.5 | 0 | – |
| Model | 15 | 7.1 ± 0.1 | 18.6 ± 0.5 | 66.7 | <0.01a |
| antagomiR NC | 15 | 7.1 ± 0.1 | 18.7 ± 0.7 | 60 | – |
| antagomiR-22 | 15 | 7.0 ± 0.4 | 18.3 ± 0.8 | 93.3 | 0.03b |
| agomiR NC | 15 | 7.1 ± 0.1 | 18.5 ± 0.5 | 73.3 | – |
| agomiR-22 | 15 | 7.1 ± 0.0 | 18.7 ± 0.6 | 20 | <0.01c |
The mice were untreated (Blank), treated with beta-aminopropionitrile and angiotensin II (Model), treated with beta-aminopropionitrile and angiotensin II, and additionally treated with miR-22 upregulation (agomiR-22), miR-22 downregulation (antagomir-22), and negative control of them. NC, normal control.
a
Model versus blank.
b
AntagomiR-22 versus antagomir NC.
c
AgomiR-22 versus agomiR NC.