Figure 3.

The Effects of miR-10a on OA Synovitis in an In Vivo PDX Model

(A) The workflow of the PDX model in vivo. (B) H&E staining in miR-10a-OE OA synovium and control OA synovium. (C) IHC staining shows the expression of human pro-inflammatory cytokines in engrafted synovial tissues. (D–G) ELISA was used to detect human pro-inflammatory cytokines in mice sera. Data represent means ± SEM (each group has six mice); ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, as determined by the Student’s t test. (D–G) *p < 0.05, **p < 0.01, compared to control group.