Figure 8.

The Effects of TWIST1 on OA Synovitis In Vivo and In Vitro

(A) H&E staining in TWIST1-OE OA synovium and control OA synovium (n = 6). (B) IHC staining shows the expression of human pro-inflammatory cytokines in engrafted synovial tissues (n = 6). (C–E) The effects of OE of TWIST1 on proliferation, migration, and production of inflammatory cytokines of OA-FLSs (n = 3). Data represent means ± SEM; ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, as determined by the Student’s t test. (C and D) *p < 0.05, **p < 0.01, compared to control group.