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. Author manuscript; available in PMC: 2020 Nov 27.
Published in final edited form as: Sci Immunol. 2020 Mar 6;5(45):eaay4209. doi: 10.1126/sciimmunol.aay4209

Figure 3. Evidence for local IgE CSR in GI tissues.

Figure 3.

(A) Two models for the generation of GI-resident IgE+ B cells. Arrows denote class-switching events (black) or transit of cells to the GI tract (red). (B) Percentage of IgE+ or total clones found in single or multiple tissue sites. (C) Percentage of IgE+ clones that contain members expressing other isotypes in the same tissue. (D) Analysis of tissue distribution of IgE sequences (x-axis) and IgM, IgD, IgG or IgA1-expressing members in the same clone (y-axis). Numbers in the boxes represent the mean number of clones identified per PA individual (n=18 for stomach and duodenum; n=19 for esophagus and blood). Shading of each box indicates the number of clones, with darker shading for increasing abundance.