Table 5.
Univariate and multivariate analysis of risk factors for recurrence
| Varables | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | p | Hazard ratio | 95% CI | p | |||
| Age ≥70 years | 0.822 | 0.48 | 1.408 | 0.475 | ||||
| Sex, male | 0.942 | 0.596 | 1.490 | 0.798 | ||||
| Cirrhosis, (P)* | 1.263 | 0.827 | 1.930 | 0.280 | ||||
| Serum albumin <4 g/dl | 1.229 | 0.737 | 2.049 | 0.429 | ||||
| Serum total bilirubin ≥1 mg/dl | 1.243 | 0.821 | 1.880 | 0.304 | ||||
| ICGR15† ≥15% | 1.510 | 1.067 | 2.138 | 0.020 | 1.549 | 1.087 | 2.207 | 0.015 |
| Prothrombin activity ≥85% | 1.027 | 0.701 | 1.504 | 0.891 | ||||
| Platelet count ≥15×104/mm3 | 0.935 | 0.662 | 1.319 | 0.701 | ||||
| Preoperative AFP ≥400 ng/ml | 1.618 | 1.029 | 2.544 | 0.037 | 1.685 | 1.061 | 2.675 | 0.027 |
| Number of tumors ≥3 (P)* | 1.672 | 1.099 | 2.542 | 0.016 | ||||
| Satellite nodule | 1.602 | 0.902 | 2.844 | 0.108 | ||||
| Tumor distribution, bilateral lobe | 1.245 | 0.765 | 2.025 | 0.378 | ||||
| Size of the largest tumor ≥3 cm (P)* | 2.008 | 1.400 | 2.88 | 0.000 | ||||
| Total tumor diameter ≥6 cm (P)* | 2.292 | 1.619 | 3.246 | 0.000 | 1.803 | 1.130 | 2.879 | 0.013 |
| Lymphovascular invasion (P)* | 1.626 | 1.094 | 2.419 | 0.016 | ||||
| Non anatomical resection | 1.458 | 0.963 | 2.208 | 0.075 | ||||
*Identified after postoperative pathological examination; †Indocyanine green retention rate at 15 min
CI, confidence interval; AFP, alpha-fetoprotein