Table 6.

Univariate and multivariate analysis of overall survival in patients with multiple hepatocellular carcinomas

Variables	Univariate				Multivariate
	Hazard ratio	95% CI		p	Hazard ratio	95% CI		p
Age ≥70 years	0.493	0.117	2.076	0.335
Sex, male	0.838	0.341	2.060	0.700
Cirrhosis, (P)*	1.191	0.484	2.926	0.704
Serum albumin <4 g/dl	0.712	0.289	1.752	0.459
Serum total bilirubin ≥1 mg/dl	0.700	0.243	2.015	0.509
ICGR15† ≥15%	2.095	0.993	4.42	0.052
Prothrombin activity ≥85%	0.532	0.253	1.116	0.095
Platelet count ≥15×104/mm3	1.052	0.507	2.184	0.891
Preoperative AFP ≥400	1.236	0.471	3.242	0.667
Number of tumors ≥3 (P)*	1.199	0.488	2.948	0.692
Satellite nodule	2.091	0.727	6.018	0.171
Tumor distribution, bilateral lobe	0.771	0.233	2.549	0.670
Size of the largest tumor ≥3 cm (P)*	2.278	1.009	5.145	0.048
Total tumor diameter ≥6 cm (±SD) (P)*	2.431	1.168	5.058	0.017	2.476	1.172	5.231	0.018
Lymphovascular invasion (P)*	1.411	0.602	3.309	0.428
Non anatomical resection	1.216	0.519	2.851	0.653

^*Identified after postoperative pathological examination; ^†Indocyanine green retention rate at 15 min

CI, confidence interval; AFP, alpha-fetoprotein