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. 2020 Nov 13;14:557170. doi: 10.3389/fnins.2020.557170

FIGURE 2.

FIGURE 2

The effect of oridonin on the expression of NLRP3 inflammasome post-TBI. (A–C) Real-time quantitative PCR analysis for NLRP3, ASC, and caspase-1 in pericontusional cerebral cortex 24 h post-TBI. (D–H) Representative immunoblot bands and quantitative analysis of NLRP3, ASC, procaspase-1, and cleaved caspase-1 in pericontusional cerebral cortex 24 h post-injury. Oridonin treatment reduced the TBI-induced upregulation of NLRP3 inflammasome in the pericontusional cerebral cortex 24 h post-injury. n = 6/group. Data are presented as the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 vs. sham group. #p < 0.05, ##p < 0.01, and ###p < 0.001 vs. TBI + vehicle group.